4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide HCl
CAS: 902135-91-5
Ref. 3D-FD32785
| 1g | 956.00 € | ||
| 2g | 1,307.00 € | ||
| 25mg | 95.00 € | ||
| 50mg | 133.00 € | ||
| 100mg | 188.00 € |
Product Information
- AT7519 HCl
- At 7519
- N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
- AT-7519(HCl)
4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide HCl (PD1693) is a small molecule that has been shown to selectively inhibit the transcriptional coactivator HIF-1α. PD1693 inhibits the hypoxic response in tumor cells by preventing the upregulation of HIF-1α. This leads to an increase in hypoxia-inducible genes, which are involved in the regulation of cell proliferation, angiogenesis and apoptosis. PD1693 also affects the expression of genes involved in metabolism and energy production. The subpopulation algorithm was used to identify differentially expressed transcripts in glioma cells following exposure to PD1693. The data from this algorithm were validated using qRT-PCR and Western blotting on human glioma cells.
Chemical properties
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