7-Diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin

CAS: 76877-33-3

Ref. 3D-FD36317

Product Information

• Name: 7-Diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin
• Synonyms: CPM, 3-(4-Maleimidophenyl)-4-methyl-7-(diethylamino)coumarin

Description

7-Diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin is a fluorescent probe that can be used to measure the cytosolic calcium concentration. This probe binds to heparin, which is a positive ionic charge and has been shown to cause an increase in cytosolic calcium levels in cultured cells. 7-Diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin has been used to successfully monitor changes in cytosolic calcium levels in response to pharmacological agents, such as the monoclonal antibody TNF-α. 7-Diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin has also been used as a marker for tissue culture studies, where it was found that this molecule binds to the ryanodine receptor and alters its redox potential.

• Brand: Biosynth

Chemical properties

• Molecular weight: 402.44 g/mol
• Formula: C₂₄H₂₂N₂O₄
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C24H22N2O4/c1-4-25(5-2)18-10-11-19-15(3)23(24(29)30-20(19)14-18)16-6-8-17(9-7-16)26-21(27)12-13-22(26)28/h6-14H,4-5H2,1-3H3
• InChI key: InChIKey=YGIABALXNBVHBX-UHFFFAOYSA-N
• SMILES: CCN(CC)c1ccc2c(C)c(-c3ccc(N4C(=O)C=CC4=O)cc3)c(=O)oc2c1