3,4-Dichloro-phenylalanine

CAS: 52794-99-7

Ref. 3D-FD38988

Product Information

• Name: 3,4-Dichloro-phenylalanine
• Synonyms: (2S)-2-Amino-3-(3,4-dichlorophenyl)propanoic acid, (2S)-2-Azaniumyl-3-(3,4-dichlorophenyl)propanoate, (S)-2-Amino-3-(3,4-dichlorophenyl)propanoic acid, 3,4-Dichloro-<span class="text-smallcaps">L</span>-phenylalanine, 3,4-dichloro-L-phenylalanine, <span class="text-smallcaps">L</span>-3,4-Dichlorophenylalanine, <span class="text-smallcaps">L</span>-Phenylalanine, 3,4-dichloro-, H-Phe(3,4-DiCl)-OH, L-3,4-Dichlorophenylalanine

Description

3,4-Dichloro-phenylalanine (3,4-DCPA) is a macrocyclic inhibitor that binds to the chaperone GroEL and inhibits protein synthesis. It has been shown to be effective against autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. 3,4-Dichloro-phenylalanine also shows potential for use in the treatment of depression, Alzheimer's disease and Parkinson's disease. This drug is currently being investigated for its role as a potential drug target for cancer treatment. 3,4-Dichloro-phenylalanine binds to human liver cells with a high affinity and has been shown to inhibit the production of glutamate. The kinetic data show that 3,4-Dichloro-phenylalanine is an irreversible inhibitor of protein synthesis with a low energy barrier.

• Brand: Biosynth

Chemical properties

• Molecular weight: 234.08 g/mol
• Formula: C₉H₉Cl₂NO₂
• Purity: Min. 95%
• InChI: InChI=1S/C9H9Cl2NO2/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14/h1-3,8H,4,12H2,(H,13,14)/t8-/m0/s1
• InChI key: InChIKey=NRCSJHVDTAAISV-QMMMGPOBSA-N
• SMILES: N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O