2,3-Diamino-5-bromopyridine

CAS: 38875-53-5

Ref. 3D-FD57703

Product Information

• Name: 2,3-Diamino-5-bromopyridine
• Synonyms: 2,3-Diamino-5-Bromopyridinium, 2,3-Pyridinediamine, 5-bromo-, 5-Bromo-2,3-pyridinediamine, 5-Bromopyridine-2,3-diamine, Pyridine, 2,3-diamino-5-bromo-

Description

2,3-Diamino-5-bromopyridine (2,3-DBP) is a unsymmetrical diamine that can be used as a cancer therapeutic. 2,3-DBP inhibits the activity of multidrug efflux pumps in cancer cells by binding to the transporter protein and inhibiting its function. This drug also inhibits glycogen synthase kinase-3 (GSK-3), which is an enzyme with tumor suppressor properties. In addition, 2,3-DBP is cytotoxic to cancer cells in vitro and has been shown to inhibit tumor growth in vivo. 2,3-DBP was shown to have an IC50 of ~8 μM for the efflux pump MDR1 and ~4 μM for Pgp. It also showed cytotoxicity against a panel of human cancer cell lines at concentrations ranging from 10 nM to 1 μM.

• Brand: Biosynth

Chemical properties

• Molecular weight: 188.03 g/mol
• Formula: C₅H₆BrN₃
• Purity: Min. 97 Area-%
• Color/Form: Powder
• InChI: InChI=1S/C5H6BrN3/c6-3-1-4(7)5(8)9-2-3/h1-2H,7H2,(H2,8,9)
• InChI key: InChIKey=YRGMYJUKFJPNPD-UHFFFAOYSA-N
• SMILES: Nc1cc(Br)cnc1N