2,3-Diamino-5-bromopyridine
CAS: 38875-53-5
Ref. 3D-FD57703
| 5g | Discontinued | ||
| 10g | Discontinued | ||
| 25g | Discontinued | ||
| 50g | Discontinued | ||
| 100g | Discontinued |
Product Information
Name:
2,3-Diamino-5-bromopyridine
Synonyms:
- 2,3-Diamino-5-Bromopyridinium
- 2,3-Pyridinediamine, 5-bromo-
- 5-Bromo-2,3-pyridinediamine
- 5-Bromopyridine-2,3-diamine
- Pyridine, 2,3-diamino-5-bromo-
- 5-Bromo-2,3-diaminopyridine
Description:
2,3-Diamino-5-bromopyridine (2,3-DBP) is a unsymmetrical diamine that can be used as a cancer therapeutic. 2,3-DBP inhibits the activity of multidrug efflux pumps in cancer cells by binding to the transporter protein and inhibiting its function. This drug also inhibits glycogen synthase kinase-3 (GSK-3), which is an enzyme with tumor suppressor properties. In addition, 2,3-DBP is cytotoxic to cancer cells in vitro and has been shown to inhibit tumor growth in vivo. 2,3-DBP was shown to have an IC50 of ~8 μM for the efflux pump MDR1 and ~4 μM for Pgp. It also showed cytotoxicity against a panel of human cancer cell lines at concentrations ranging from 10 nM to 1 μM.
Notice:
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Brand:
Biosynth
Long term storage:
Notes:
Chemical properties
Molecular weight:
188.03 g/mol
Formula:
C5H6BrN3
Purity:
Min. 97 Area-%
Color/Form:
Powder
InChI:
InChI=1S/C5H6BrN3/c6-3-1-4(7)5(8)9-2-3/h1-2H,7H2,(H2,8,9)
InChI key:
InChIKey=YRGMYJUKFJPNPD-UHFFFAOYSA-N
SMILES:
Nc1cc(Br)cnc1N
MDL:
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HS code:
