1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]echinocandin B

CAS: 79411-15-7

Ref. 3D-FD61520

Product Information

• Name: 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]echinocandin B
• Synonyms: Echinocandin B nucleus, 1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacycloheneicosine-5,8,14,19,22,25(9H,25aH)-hexone, 9-amino-23-[1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]hexadecahydro-2,11,12,15-tetrahydroxy-6,20-bis(1-hydroxyethyl)-16-methyl-, 9-Amino-23-[1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6,20-bis(1-hydroxyethyl)-16-methylhexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-5,8,14,19,22,25(9H,25aH)-hexone
• CAS: 79411-15-7

Description

1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]echinocandin B is an antifungal drug that belongs to the class of echinocandins. It has a broad spectrum of activity against filamentous fungi and yeasts. Echinocandins inhibit the synthesis of β-(1→3) glucan in the fungal cell wall by binding to the enzyme 1,3-β-(1→3)-glucan synthase. The drug is resistant to deacetylation by acetohydroxyacid synthase and therefore does not require activation with glucose-6-phosphate. This product is soluble in water and can be used for phase chromatography on a C18 column with a mobile phase of methanol/water (80/20).

• Brand: Biosynth

Chemical properties

• Molecular weight: 797.81 g/mol
• Formula: C₃₄H₅₁N₇O₁₅
• Purity: Min. 95%
• InChI: InChI=1S/C34H51N7O15/c1-12-10-41-24(25(12)47)32(54)39-30(52)20(46)9-18(35)28(50)36-21(13(2)42)33(55)40-11-17(45)8-19(40)29(51)38-23(31(53)37-22(14(3)43)34(41)56)27(49)26(48)15-4-6-16(44)7-5-15/h4-7,12-14,17-27,30,42-49,52H,8-11,35H2,1-3H3,(H,36,50)(H,37,53)(H,38,51)(H,39,54)
• InChI key: InChIKey=BLKJKIJFNJAQIZ-UHFFFAOYSA-N
• SMILES: CC(O)C1NC(=O)C(N)CC(O)C(O)NC(=O)C2C(O)C(C)CN2C(=O)C(C(C)O)NC(=O)C(C(O)C(O)c2ccc(O)cc2)NC(=O)C2CC(O)CN2C1=O