Product Information
- Ccris 8776
- 6,8-Difluoroquinoline
6,8-Difluoroquinoline is an antibiotic that inhibits the growth of bacteria by binding to the 50S ribosomal subunit. It has been shown to inhibit the production of tumour necrosis factor-α (TNF-α) and serum enzymes, such as dismutase activity, in mice with lung cancer. This drug also has a toxic effect on respiratory system cells, which may be due to its ability to induce apoptosis. 6,8-Difluoroquinoline binds to penicillin-binding proteins in the bacterial cell wall by competitive inhibition. This binding prevents the formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division. 6,8-Difluoroquinoline also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell
Chemical properties
Technical inquiry about: 3D-FD77486 6,8-Difluoroquinoline
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