3-[2-(Dimethylamino)Ethoxy]-1-[3-(Trifluoromethyl)Phenyl]-1H-Indazole

CAS: 21487-12-7

Ref. 3D-FD98694

Product Information

• Name: 3-[2-(Dimethylamino)Ethoxy]-1-[3-(Trifluoromethyl)Phenyl]-1H-Indazole

Description

3-[2-(Dimethylamino)Ethoxy]-1-[3-(Trifluoromethyl)Phenyl]-1H-Indazole is an aporphine alkaloid with anti-cancer, trypanocidal and antineoplastic activities. It binds to DNA as a potent inhibitor of DNA synthesis and RNA polymerase. 3-[2-(Dimethylamino)Ethoxy]-1-[3-(Trifluoromethyl)Phenyl]-1H-Indazole inhibits cell proliferation by binding to the beta subunit of human DNA polymerase II, blocking the extension of the 3'-end of the growing DNA strand. In addition, it prevents transcription by inhibiting RNA polymerase from transcribing messenger RNA (mRNA). 3-[2-(Dimethylamino)Ethoxy]-1-[3-(Trifluoromethyl)Phenyl]-1H-Indazole also has antiplas

• Brand: Biosynth

Chemical properties

• Molecular weight: 349.35 g/mol
• Formula: C₁₈H₁₈F₃N₃O
• Purity: Min. 95%
• InChI: InChI=1S/C18H18F3N3O/c1-23(2)10-11-25-17-15-8-3-4-9-16(15)24(22-17)14-7-5-6-13(12-14)18(19,20)21/h3-9,12H,10-11H2,1-2H3
• InChI key: InChIKey=PZVXOQBSEVRLKE-UHFFFAOYSA-N
• SMILES: CN(C)CCOc1nn(-c2cccc(C(F)(F)F)c2)c2ccccc12