2-Ethyl-6-hydroxypyrimidin-4(3H)-one

CAS: 3709-98-6

Ref. 3D-FE123957

Product Information

• Name: 2-Ethyl-6-hydroxypyrimidin-4(3H)-one
• Synonyms: 4(3H)-pyrimidinone, 2-ethyl-6-hydroxy-, 2-Ethylpyrimidine-4,6-diol, 4,6-Pyrimidinediol, 2-Ethyl-

Description

2-Ethyl-6-hydroxypyrimidin-4(3H)-one is an intermediate in the synthesis of the drug propionamide. It can be prepared by reacting ethyl pyrimidine-2,4(1H,3H)-dione with diethyl chloroacetate in the presence of a catalyst such as sodium methoxide. The reaction time can vary from one to three hours and the optimal reaction temperature is between 50°C and 60°C. 2-Ethyl-6-hydroxypyrimidin-4(3H)-one can also be prepared using propionitrile and alkali solution. This process takes approximately four hours to complete, but yields a greater quantity of product than when using diethyl chloroacetate.

• Brand: Biosynth

Chemical properties

• Molecular weight: 140.14 g/mol
• Formula: C₆H₈N₂O₂
• Purity: Min. 95%
• InChI: InChI=1S/C6H8N2O2/c1-2-4-7-5(9)3-6(10)8-4/h3H,2H2,1H3,(H2,7,8,9,10)
• InChI key: InChIKey=CBXPKEZRCKCOID-UHFFFAOYSA-N
• SMILES: CCc1nc(O)cc(=O)[nH]1