Estradiolbis[4-[bis(2-chloroethyl)amino]benzeneacetate]

CAS: 22966-79-6

Ref. 3D-FE150020

Product Information

• Name: Estradiolbis[4-[bis(2-chloroethyl)amino]benzeneacetate]
• Synonyms: (17Beta)-Estra-1,3,5(10)-Triene-3,17-Diyl Bis({4-[Bis(2-Chloroethyl)Amino]Phenyl}Acetate), (17Beta)-Estra-1,3,5(10)-Triene-3,17-Diyl Bis{4-[Bis(2-Chloroethyl)Amino]Benzoate}, (17b)-Estra-1,3,5(10)-triene-3,17-diol bis[4-[bis(2-chloroethyl)amino]benzeneacetate], Acetic acid, [p-[bis(2-chloroethyl)amino]phenyl]-, diester with estradiol, Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3,17-bis[4-[bis(2-chloroethyl)amino]benzeneacetate], Estra-1,3,5(10)-triene-3,17-diol (17β)-, bis[4-[bis(2-chloroethyl)amino]benzeneacetate], Estradiol mustard, Estradiol, bis[[p-[bis(2-chloroethyl)amino]phenyl]acetate], NSC 112259

Description

Estradiolbis[4-[bis(2-chloroethyl)amino]benzeneacetate] is a prodrug of estradiol that has been shown to have anticancer activity. It has been demonstrated that, in Sprague-Dawley rats, estradiolbis[4-[bis(2-chloroethyl)amino]benzeneacetate] inhibits the growth of breast cancer cells and induces death protein (p53). The molecular modeling studies show that estradiolbis[4-[bis(2-chloroethyl)amino]benzeneacetate] binds to the ATP binding site on the enzyme malic acid pyrophosphatase. This binding prevents the formation of an active complex between malic acid and ATP, leading to cell death. This drug also showed anticancer activity in mice with lymphocytic leukemia (LLC), but not in low doses. Estradiolbis[4-[bis(

• Brand: Biosynth

Chemical properties

• Molecular weight: 788.67 g/mol
• Formula: C₄₂H₅₀Cl₄N₂O₄
• Purity: Min. 95%