5-Ethyl-2-thiouracil

CAS: 34171-37-4

Ref. 3D-FE153683

Product Information

• Name: 5-Ethyl-2-thiouracil

Description

5-Ethyl-2-thiouracil (5ET) is an inhibitor of uridine phosphorylase and inhibits the synthesis of uridine. It has been shown to inhibit muscle tissue, which may be due to its inhibition of 5'-nucleotidase. 5ET has also been shown to have antitumor activity against Toxoplasma in mice and is oriented with a mass spectrometric detection. The disulfonate group of 5ET has been shown to inhibit the enzyme's activity in a linear range from 0.3 mM to 10 mM, while the methyl ester group is active at concentrations below 0.1 mM. Studies have found that 5ET inhibits the kinetics of uridine phosphorylase by binding to the enzyme's active site, preventing substrate binding and catalysis.

• Brand: Biosynth

Chemical properties

• Molecular weight: 156.21 g/mol
• Formula: C₆H₈N₂OS
• Purity: Min. 95%
• InChI: InChI=1S/C6H8N2OS/c1-2-4-3-7-6(10)8-5(4)9/h3H,2H2,1H3,(H2,7,8,9,10)
• InChI key: InChIKey=JYBWJPAOAQCXAX-UHFFFAOYSA-N
• SMILES: CCc1c[nH]c(=S)[nH]c1=O