Eflornithine hydrochloride

CAS: 68278-23-9

Ref. 3D-FE168402

Product Information

• Name: Eflornithine hydrochloride
• Synonyms: 2,5-Diamino-2-(difluoromethyl)pentanoic acid hydrochloride, 2-(Difluoromethyl)-DL-ornithine monohydrochloride, 2-(Difluoromethyl)Ornithine Hydrochloride (1:1), 2-(Difluoromethyl)Ornithine Hydrochloride Hydrate, <span class="text-smallcaps">DL</span>-Ornithine, 2-(difluoromethyl)-, monohydrochloride, DFMO HCl, Eflornithine HCl, Eflornithine HCl(anhydrous), Flornithine, Flornithine Hcl, Flornithine Hydrochloride, Fmo Hcl, Fmo Hydrochloride, L-Alpha-Difluoromethylornithine Hydrochloride, NSC 270295, NSC 337250, Ornithine, 2-(difluoromethyl)-, hydrochloride (1:1), Ornithine, 2-(difluoromethyl)-, monohydrochloride, Vaniqa

Description

Eflornithine is a drug that inhibits polyamine synthesis. It has been used in combination with nonsteroidal anti-inflammatory drugs for the treatment of cardiac arrhythmias, angina pectoris, and congestive heart failure. Eflornithine hydrochloride is also an inhibitor of DNA topoisomerases I and II. These enzymes are important in the regulation of DNA replication and transcription. The inhibition of these enzymes leads to cell death by inhibiting phosphorylation reactions required for the production of DNA. Eflornithine hydrochloride has minimal toxicity and is not known to cause toxic effects on the heart, lungs or kidneys.

• Brand: Biosynth

Chemical properties

• Molecular weight: 218.63 g/mol
• Formula: C₆H₁₃ClF₂N₂O₂
• Purity: Min. 95%