Ethyl imidazole-4-carboxylate
CAS: 23785-21-9
Ref. 3D-FE29318
| 1g | Discontinued | ||
| 2g | Discontinued | ||
| 5g | Discontinued | ||
| 10g | Discontinued | ||
| 25g | Discontinued |
Product Information
Name:
Ethyl imidazole-4-carboxylate
Synonyms:
- Ethyl Imidazole-4-Carboxylate
- ethyl 1H-imidazole-5-carboxylate
- ethyl 1H-imidazole-2-carboxylate
Description:
Ethyl imidazole-4-carboxylate is a synthetic compound that has been shown to have in vitro cytotoxic activity against various cancer cell lines. It is an ethyl ester of 4-hydroxyimidazole with an alkylating group at the 4 position on the phenyl ring. This compound binds to DNA by reacting with the N7 nitrogen atom of guanine and forming a covalent bond. The resulting adduct is resistant to nucleases and can form crosslinks between DNA molecules, leading to cell death. Ethyl imidazole-4-carboxylate also reacts with other sites on DNA, such as the 5′ phosphate group of deoxyribose and the 3′ hydroxyl group of ribose, which lead to further cytotoxic effects.
Notice:
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Brand:
Biosynth
Long term storage:
Notes:
Chemical properties
Molecular weight:
140.14 g/mol
Formula:
C6H8N2O2
Purity:
Min. 95%
Color/Form:
Powder
InChI:
InChI=1S/C6H8N2O2/c1-2-10-6(9)5-3-7-4-8-5/h3-4H,2H2,1H3,(H,7,8)
InChI key:
InChIKey=KLWYPRNPRNPORS-UHFFFAOYSA-N
SMILES:
CCOC(=O)c1cnc[nH]1
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