Ethyl imidazole-4-carboxylate

CAS: 23785-21-9

Ref. 3D-FE29318

Product Information

• Name: Ethyl imidazole-4-carboxylate
• Synonyms: Ethyl Imidazole-4-Carboxylate, ethyl 1H-imidazole-5-carboxylate, ethyl 1H-imidazole-2-carboxylate
• CAS: 23785-21-9

Description

Ethyl imidazole-4-carboxylate is a synthetic compound that has been shown to have in vitro cytotoxic activity against various cancer cell lines. It is an ethyl ester of 4-hydroxyimidazole with an alkylating group at the 4 position on the phenyl ring. This compound binds to DNA by reacting with the N7 nitrogen atom of guanine and forming a covalent bond. The resulting adduct is resistant to nucleases and can form crosslinks between DNA molecules, leading to cell death. Ethyl imidazole-4-carboxylate also reacts with other sites on DNA, such as the 5′ phosphate group of deoxyribose and the 3′ hydroxyl group of ribose, which lead to further cytotoxic effects.

• Brand: Biosynth

Chemical properties

• Molecular weight: 140.14 g/mol
• Formula: C₆H₈N₂O₂
• Purity: Min. 95%
• Color/Form: Solid
• InChI: InChI=1S/C6H8N2O2/c1-2-10-6(9)5-3-7-4-8-5/h3-4H,2H2,1H3,(H,7,8)
• InChI key: InChIKey=KLWYPRNPRNPORS-UHFFFAOYSA-N
• SMILES: CCOC(=O)c1cnc[nH]1