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6-Ethyl-5-(4-Fluoro-3-Nitrophenyl)Pyrimidine-2,4-Diamine
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6-Ethyl-5-(4-Fluoro-3-Nitrophenyl)Pyrimidine-2,4-Diamine

CAS: 113494-35-2

Ref. 3D-FE94781

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Estimated delivery in United States, on Tuesday 10 Dec 2024

Product Information

Name:
6-Ethyl-5-(4-Fluoro-3-Nitrophenyl)Pyrimidine-2,4-Diamine
Synonyms:
  • 4'-Fluoro-3'-nitropyrimethamine
  • 4-Fnpm
Description:

6-Ethyl-5-(4-fluoro-3-nitrophenyl)pyrimidine-2,4-diamine is an antifolate that inhibits the enzyme dihydrofolate reductase. The ligand binds to the target enzyme with a high affinity and the binding affinities of the two isomers are different. The enantiomeric mixture of 6-ethyl-5-(4-fluoro-3-nitrophenyl)pyrimidine-2,4-diamine has been shown to have potent antifolate activity against methotrexate resistant cells in vitro and in vivo. Spectroscopy studies have shown that this molecule exists as enantiomers, which can be interconverted by reductases (e.g., NADPH). The interconversion rate is dependent on the concentration of reductase and the pH of the solution. The conformational changes in the ligand are slow and are detectable

Notice:
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Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
277.25 g/mol
Formula:
C12H12FN5O2
Purity:
Min. 95%
MDL:
Melting point:
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Density:
Concentration:
EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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