5-fluoropyridine-2-carbaldehyde
CAS: 31181-88-1
Ref. 3D-FF104386
| 1g | Discontinued | ||
| 2g | Discontinued | ||
| 100mg | Discontinued | ||
| 250mg | Discontinued | ||
| 500mg | Discontinued |
Product Information
- 1-Propanol, 2-Bromo-3,3,3-Trifluoro-
- 2-Bromo-3,3,3-trifluoro-1-propanol
- 5-Fluoropyridine-2-Carbaldehyde
- 5-Fluoro-2-formylpyridine
5-Fluoropyridine-2-carbaldehyde is a ligand that inhibits the JAK2 kinase. It has been shown to inhibit bacterial growth and is used as a potential antibiotic. 5-Fluoropyridine-2-carbaldehyde binds to amines, organometallic compounds, and diphenyl ethers in its coordination complex with zinc ions. The compound can be synthesized with cross-coupling reactions using 2 equivalents of the appropriate metal halide and 1 equivalent of the amine or diphenyl ether ligand. The synthesis yields are dependent on the nature of the reactants, but typically range from 30% to 50%. 5-Fluoropyridine-2-carbaldehyde has a pharmacokinetic profile that is linear over a wide dose range and exhibits no accumulation in plasma. The chemical structure of this compound is similar to that of imines and alkylating agents, which may account for its mechanism of action
