3-(2-Furyl)-1H-1,2,4-triazol-5-amine

CAS: 3663-61-4

Ref. 3D-FF125698

Product Information

• Name: 3-(2-Furyl)-1H-1,2,4-triazol-5-amine
• Synonyms: 1H-1,2,4-triazol-5-amine, 3-(2-furanyl)-, 1H-1,2,4-Triazol-3-amine, 5-(2-furanyl)-, 1H-1,2,4-triazol-5-amine, 3-(2-furanyl)-, 3-(2-Furanyl)-1H-1,2,4-triazol-5-amine, 3-(Furan-2-yl)-1H-1,2,4-triazol-5-amine, 3-Amino-5-(2-furyl)-1,2,4-triazole, 3-Amino-5-(furan-2-yl)-1H-1,2,4-triazole, 4H-1,2,4-triazol-3-amine, 5-(2-furanyl)-, 5-(2-Furyl)-4H-1,2,4-triazol-3-amine, 5-(furan-2-yl)-4H-1,2,4-triazol-3-amine, s-Triazole, 3-amino-5-(2-furyl)-

Description

3-(2-Furyl)-1H-1,2,4-triazol-5-amine is a pharmacological agent that is used in the treatment of pulmonary hypertension. It has a nitric oxide donor activity and can be synthesized using 2-furyl nitration. This compound has been shown to inhibit adenosine receptors and block adenosine signaling. 3-(2-Furyl)-1H-1,2,4-triazol-5-amine has affinity for the A1 receptor with an IC50 of 0.5 μM and inhibits adenosine binding with an IC50 of 1 μM.
This drug also has a high degree of specificity for A2A receptors with an IC50 of 5 μM. 3-(2-Furyl)-1H-1,2,4-triazol-5-amine is active in vivo as well as in vitro.

• Brand: Biosynth

Chemical properties

• Molecular weight: 150.14 g/mol
• Formula: C₆H₆N₄O
• Purity: Min. 95%
• InChI: InChI=1S/C6H6N4O/c7-6-8-5(9-10-6)4-2-1-3-11-4/h1-3H,(H3,7,8,9,10)
• InChI key: InChIKey=PXCDIRKSCUAMKA-UHFFFAOYSA-N
• SMILES: Nc1n[nH]c(-c2ccco2)n1