Product Information
- 1H-imidazole-4-carboxylic acid, 5-formyl-, methyl ester
- Methyl 5-formyl-1H-imidazole-4-carboxylate
5-Formylimidazole-4-carboxylic acid methylester (5FICM) is a small molecule that has been shown to inhibit the growth of cells by blocking the TNF-α receptor. The molecular modeling data and crystallographic data indicate that 5FICM can bind to the kinase domain of TNF-α receptors, preventing activation of downstream signaling pathways. In knockout mice, 5FICM was found to reduce skin inflammation caused by LPS. It also inhibited tumor necrosis factor (TNF)-α production in epidermal growth factor (EGF)-treated human keratinocytes and inhibited EGF-induced epidermal growth. These data suggest that 5FICM may be a potential therapeutic agent for inflammatory skin diseases, such as psoriasis and atopic dermatitis.
Chemical properties
Technical inquiry about: 3D-FF151158 5-Formylimidazole-4-carboxylic acid methylester
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