Product Information
- ZM 218463(3R,4R,5S,6R)-6-Fluoro-3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid
(6R)-6-Fluoroshikimic acid is a synthetic, enantiopure antimicrobial agent that inhibits microbial growth by inhibiting the shikimate pathway. The active form of (6R)-6-fluoroshikimic acid binds to the enzyme dihydroxylase, which converts shikimic acid into 3-deoxybenzoic acid and then into 3-dehydroquinate. This compound also inhibits the synthesis of aromatic amino acids by competing with phenylalanine for access to the enzyme phenylalanine hydroxylase. The inhibition of this enzyme leads to a decrease in the production of dopamine, norepinephrine, and serotonin. (6R)-6-Fluoroshikimic acid has shown activity against a variety of bacteria including Bacillus subtilis and Escherichia coli. It has also been shown to inhibit Candida albicans yeast growth in culture.
Chemical properties
Technical inquiry about: 3D-FF161982 (6R)-6-Fluoroshikimic acid
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