FlAsH-EDT2

CAS: 212118-77-9

Ref. 3D-FF23296

Product Information

• Name: FlAsH-EDT2
• Synonyms: 4',5'-Bis(1,3,2-dithiarsolan-2-yl)-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-oneFlAsHFluorescein arsenical helix binder
• CAS: 212118-77-9

Description

FlAsH-EDT2 is a red fluorescent dye that binds to calcium ions. It has been shown to inhibit the growth of wild-type herpes simplex virus, while not affecting the growth of recombinant viruses with mutated sequences. FlAsH-EDT2 binds to the kinase domain of soluble guanylate cyclase and inhibits its activity, thereby inhibiting cellular proliferation in response to extracellular growth factors. This inhibition can be reversed by removing excess calcium ions from the system. The binding of FlAsH-EDT2 to calcium ions also results in changes in electrophysiological properties.

• Brand: Biosynth

Chemical properties

• Molecular weight: 664.5 g/mol
• Formula: C₂₄H₁₈As₂O₅S₄
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C24H18As2O5S4/c27-17-7-5-15-21(19(17)25-32-9-10-33-25)30-22-16(6-8-18(28)20(22)26-34-11-12-35-26)24(15)14-4-2-1-3-13(14)23(29)31-24/h1-8,27-28H,9-12H2
• InChI key: InChIKey=AJNUQUGWNQHQDJ-UHFFFAOYSA-N
• SMILES: O=C1OC2(c3ccccc31)c1ccc(O)c([As]3SCCS3)c1Oc1c2ccc(O)c1[As]1SCCS1