5-Fluoro-4-hydroxy-2-methoxypyrimidine

CAS: 1480-96-2

Ref. 3D-FF23404

Product Information

• Name: 5-Fluoro-4-hydroxy-2-methoxypyrimidine
• Synonyms: 5-Fluoro-2-methoxy-4(1H)pyrimidinoneNSC 5270672-Methoxy-5-fluorouracil, 2-Methoxy-4-hydroxy-5-fluoropyrimidine, 2-Methoxy-5-fluorouracil, 4(1H)-Pyrimidinone, 5-fluoro-2-methoxy-, 4(3H)-Pyrimidinone, 5-fluoro-2-methoxy-, 5-Fluoro-2-methoxy-4(3H)-pyrimidinone, 5-Fluoro-2-methoxy-pyrimidin-4-ol, 5-fluoro-2-methoxypyrimidin-4(3H)-one, NSC 527067
• CAS: 1480-96-2

Description

5-Fluoro-4-hydroxy-2-methoxypyrimidine (5FMMP) is a chemical intermediate that is used in the synthesis of various pharmaceuticals, including antibiotics. It can be obtained by reacting phosphorus oxychloride with activated 2-methoxybenzaldehyde. This chemical intermediate is highly reactive and has been shown to be virulent against some strains of bacteria, such as E. coli and Proteus mirabilis. 5FMMP binds to the bacterial cell wall using its primary amine group, which prevents the formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division. The chlorinating reaction between 5FMMP and sodium hypochlorite results in hydrochloric acid generation. This chemical intermediate can also be synthesized from recycled chemicals such as ethyl chloride or chloroform.

• Brand: Biosynth

Chemical properties

• Molecular weight: 144.1 g/mol
• Formula: C₅H₅FN₂O₂
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C5H5FN2O2/c1-10-5-7-2-3(6)4(9)8-5/h2H,1H3,(H,7,8,9)
• InChI key: InChIKey=VMIFBCPINLZNNI-UHFFFAOYSA-N
• SMILES: COc1ncc(F)c(=O)[nH]1