Fosinoprilat disodium salt

CAS: 95399-71-6

Ref. 3D-FF23599

Product Information

• Name: Fosinoprilat disodium salt
• Synonyms: (4S)-4-Cyclohexyl-1-[2-[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-L-proline disodium saltFosfenopril disodium saltFosinoprilic acid disodium salt, (4S)-4-Cyclohexyl-1-((hydroxy(4-phenylbutyl)phosphinyl)acetyl)-L-proline, (4S)-4-Cyclohexyl-1-[2-[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-<span class="text-smallcaps">L</span>-proline, (4S)-4-cyclohexyl-1-{[hydroxy(4-phenylbutyl)phosphoryl]acetyl}-L-proline, <span class="text-smallcaps">L</span>-Proline, 4-cyclohexyl-1-[2-[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-, (4S)-, <span class="text-smallcaps">L</span>-Proline, 4-cyclohexyl-1-[[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-, (4S)-, <span class="text-smallcaps">L</span>-Proline, 4-cyclohexyl-1-[[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-, trans-, Fosfenopril, Fosinopril diacid, Fosinoprilat [USAN:INN], Fosinoprilatum, Fosinoprilatum [INN-Latin], Fosinoprilic acid, L-Proline, 4-cyclohexyl-1-((hydroxy(4-phenylbutyl)phosphinyl)acetyl)-, trans-, Sq 27,519, Unii-S312Ey6Zt8

Description

Fosinoprilat is a prodrug of enalaprilat that has been shown to be as effective as enalapril in the treatment of congestive heart failure. Fosinoprilat is rapidly converted to enalaprilat, which inhibits angiotensin-converting enzyme (ACE) and prevents the formation of angiotensin II, a potent vasoconstrictor. The matrix effect is an important factor for the bioavailability of drugs in humans. A two-way crossover study on human volunteers found that fosinoprilat increased plasma concentrations of enalaprilat by up to 40%. Fosinopril binds to toll-like receptor 4, which may contribute to its pharmacokinetic properties.

• Brand: Biosynth

Chemical properties

• Molecular weight: 479.46 g/mol
• Formula: C₂₃H₃₂NNa₂O₅P
• Purity: Min. 95%