Fmoc-N-methyl-O-tert-butyl-L-serine

CAS: 197632-77-2

Ref. 3D-FF29722

Product Information

• Name: Fmoc-N-methyl-O-tert-butyl-L-serine
• Synonyms: N-Alpha-(9-Fluorenylmethyloxycarbonyl)-N-Alpha-Methyl-O-T-Butyl-L-Serine, N-Alpha-(9-Fluorenylmethyloxycarbonyl)-N-Alpha-Methyl-O-Tert-Butyl-L-Serine, N-Alpha-(9-Fluorenylmethoxycarbonyl)-N-Alpha-Methyl-O-T-Butyl-L-Serine, Fmoc-N-Alpha-Methyl-O-T-Butyl-L-Serine, Fmoc-Meser(Tbu)-Oh, Fmoc-N-Methyl-O-T-Butyl-L-Serine, Fmoc-N-Me-Serine(Tbu)-Oh, Fmoc-N-Me-Ser(Tbu)-Oh, O-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-serine

Description

Fmoc-N-methyl-O-tert-butyl-L-serine is a protease inhibitor that inhibits the activity of serine proteases. It has been shown to inhibit trypsin, chymotrypsin, and elastase in vitro. This drug is a peptide mimetic with a systematic sequence that has been modified to include maximal modifications at sites where amino acids are susceptible to hydrolysis by endogenous proteases. These modifications prevent degradation of the active form by endogenous proteases and increase the half-life of Fmoc-N-methyl-O-tert-butyl-L-serine in vivo. The minimal nature of this compound makes it ideal for use as a probe for protein interactions, as it can be used to identify sites on proteins that are involved in protein interactions.

• Brand: Biosynth

Chemical properties

• Molecular weight: 397.46 g/mol
• Formula: C₂₃H₂₇NO₅
• Purity: Min. 95%
• InChI: InChI=1S/C23H27NO5/c1-23(2,3)29-14-20(21(25)26)24(4)22(27)28-13-19-17-11-7-5-9-15(17)16-10-6-8-12-18(16)19/h5-12,19-20H,13-14H2,1-4H3,(H,25,26)/t20-/m0/s1
• InChI key: InChIKey=PQSAXALAXPNFMG-FQEVSTJZSA-N
• SMILES: CN(C(=O)OCC1c2ccccc2-c2ccccc21)[C@@H](COC(C)(C)C)C(=O)O