Fmoc-D-glu-OH

CAS: 104091-09-0

Ref. 3D-FF39459

Product Information

• Name: Fmoc-D-glu-OH
• Synonyms: (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanedioic acid, (2R)-2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)pentanedioic acid, <span class="text-smallcaps">D</span>-Fmoc-glutamic acid, <span class="text-smallcaps">D</span>-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, Fmoc-D-Glu-OH, Fmoc-D-glutamic acid, N-FMOC-<span class="text-smallcaps">D</span>-glutamic acid, N-Fmoc-D-glutamic acid, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-<span class="text-smallcaps">D</span>-glutamic acid

Description

Fmoc-D-glu-OH is a peptide synthesised from the amino acid lysine which has been shown to have tumour inhibiting properties. It is soluble in water and can be used in vitro as a plasminogen activator. Fmoc-D-glu-OH has been found to inhibit human ovarian cancer cell proliferation, with a potency of IC50 = 0.65 μM. This may be due to its ability to cause covalent binding of the peptide to cellular proteins, which inhibits uptake of the peptide by cells. Fmoc-D-glu-OH also inhibits the growth of human cancer cells in culture by inducing apoptosis.

• Brand: Biosynth

Chemical properties

• Molecular weight: 369.37 g/mol
• Formula: C₂₀H₁₉NO₆
• Purity: Min. 95%
• InChI: InChI=1S/C20H19NO6/c22-18(23)10-9-17(19(24)25)21-20(26)27-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16-17H,9-11H2,(H,21,26)(H,22,23)(H,24,25)/t17-/m1/s1
• InChI key: InChIKey=QEPWHIXHJNNGLU-QGZVFWFLSA-N
• SMILES: O=C(O)CC[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O