Fmoc-L-proline N-hydroxysuccinimide ester

CAS: 109074-94-4

Ref. 3D-FF47355

Product Information

• Name: Fmoc-L-proline N-hydroxysuccinimide ester
• Synonyms: Fmoc-L-Pro-OSu, Fmoc-L-Proline Hydroxysuccinimide Ester, Fmoc-L-Proline N-Hydroxysuccinimide Ester, NALPHA-9-Fluorenylmethoxycarbonyl-L-proline N-hydroxysuccinimide ester, N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-proline succinimidyl ester, Fmoc-L-Proline Hydroxysuccinimidester
• CAS: 109074-94-4

Description

Fmoc-L-proline N-hydroxysuccinimide ester is a high performance liquid chromatography (HPLC) reagent used in the synthesis of bivalirudin. It is a tripeptide that is synthesized by reacting L-proline with succinic anhydride, followed by reaction with hydroxysuccinimide, and finally coupling with N-hydroxysuccinimide ester. The product can be purified by recrystallization or liquid chromatography. This reagent has been shown to be effective for the production of pentapeptides under mild reaction conditions. Fmoc-L-proline N-hydroxysuccinimide ester is also stable and high yielding.

• Brand: Biosynth

Chemical properties

• Molecular weight: 434.44 g/mol
• Formula: C₂₄H₂₂N₂O₆
• Purity: Min. 95%
• Color/Form: Solid
• InChI: InChI=1S/C24H22N2O6/c27-21-11-12-22(28)26(21)32-23(29)20-10-5-13-25(20)24(30)31-14-19-17-8-3-1-6-15(17)16-7-2-4-9-18(16)19/h1-4,6-9,19-20H,5,10-14H2/t20-/m0/s1
• InChI key: InChIKey=JZBHVBQPWXZALQ-FQEVSTJZSA-N
• SMILES: O=C(ON1C(=O)CCC1=O)[C@@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21