Fmoc-3-(1-naphthyl)-D-alanine

CAS: 138774-93-3

Ref. 3D-FF47419

Product Information

• Name: Fmoc-3-(1-naphthyl)-D-alanine
• Synonyms: Fmoc-D-Ala(1-naphthyl)-OH, (r)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-naphthalen-1-yl-propionic acid, (αR)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-1-naphthalenepropanoic acid, 1-Naphthalenepropanoic acid, α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (R)-, 1-Naphthalenepropanoic acid, α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (αR)-, Fmoc-1-D-Nal-OH, Fmoc-D-1-Nal-OH, Fmoc-D-1-Naphthylalanine, Fmoc-D-3-(1-Naphthyl)-alanine

Description

Fmoc-3-(1-naphthyl)-D-alanine is a selective inhibitor of the class I human geranylgeranyltransferase. It binds to the imidazole ring and prevents the enzyme from binding to its protein substrate, thereby inhibiting protein synthesis. Fmoc-3-(1-naphthyl)-D-alanine has shown activity against Candida albicans and C.albicans, but not against other fungi or bacteria. This inhibitor is synthesized on a solid phase and can be screened for activity using candida cells grown in liquid culture.

• Brand: Biosynth

Chemical properties

• Molecular weight: 437.49 g/mol
• Formula: C₂₈H₂₃NO₄
• Purity: Min. 95%
• InChI: InChI=1S/C28H23NO4/c30-27(31)26(16-19-10-7-9-18-8-1-2-11-20(18)19)29-28(32)33-17-25-23-14-5-3-12-21(23)22-13-4-6-15-24(22)25/h1-15,25-26H,16-17H2,(H,29,32)(H,30,31)/t26-/m1/s1
• InChI key: InChIKey=ORWNVJDLEMVDLV-AREMUKBSSA-N
• SMILES: O=C(N[C@H](Cc1cccc2ccccc12)C(=O)O)OCC1c2ccccc2-c2ccccc21