Furil

CAS: 492-94-4

Ref. 3D-FF70260

Product Information

• Name: Furil
• Synonyms: 1,2-Bis(2-furanyl)-1,2-ethanedione, 1,2-Bis(2-furyl)-1,2-ethanedione, 1,2-Bis(2-furyl)ethanedione, 1,2-Bis(furan-2-yl)ethanedione, 1,2-Di(2-furanyl)-1,2-ethanedione, 1,2-Di(2-furyl)ethane-1,2-dione, 1,2-Di(2-furyl)ethanedione, 1,2-Di(Furan-2-Yl)Ethane-1,2-Dione, 1,2-Di-2-furylethane-1,2-dione, 1,2-Ethanedione, 1,2-di-2-furanyl-, 2,2-Furil, 98%, 2,2′-Furil, Bipyromucyl, Di-2-furanylethanedione, Difuranylglyoxal, Ethanedione, di-2-furanyl-, NSC 5561, α-Furil
• CAS: 492-94-4

Description

Furil is a pharmaceutical preparation used for the treatment of metabolic disorders, such as hypertension and diabetes. Furil is an inhibitor of the enzyme acyl coenzyme A: diacylglycerol acyltransferase-2 (DGAT-2) which catalyses the formation of triacylglycerols from diacylglycerol and free fatty acids. Furil has been shown to have potent inhibitory activity against DGAT-2, with an IC50 value of 0.5 μM. Furil also inhibits the enzyme phosphodiesterase 4B (PDE4B), which plays a role in signal transduction and inflammation. Furil can be synthesized by reacting hydrogen chloride with 2-bromoacetophenone in a nonpolar solvent to form 2,4-dichlorobenzoyl chloride, followed by reaction with 3-furancarboxylic acid in methanol to produce furil. Furil

• Brand: Biosynth

Chemical properties

• Molecular weight: 190.15 g/mol
• Formula: C₁₀H₆O₄
• Purity: Min. 95%
• Color/Form: Beige Powder
• InChI: InChI=1S/C10H6O4/c11-9(7-3-1-5-13-7)10(12)8-4-2-6-14-8/h1-6H
• InChI key: InChIKey=SXPUVBFQXJHYNS-UHFFFAOYSA-N
• SMILES: O=C(C(=O)c1ccco1)c1ccco1