Product Information
- 1H-Indole,5-fluoro-2,3-dihydro-2,2-dimethyl-(9CI)
5-fluoro-2,2-dimethyl-indoline is an amide that acts as a cyclic ether. The compound has been shown to be orally bioavailable and is active against Gram-positive bacteria. It is also a lead compound for the development of new antibiotics. 5-fluoro-2,2-dimethyl-indoline targets the active site of bacterial enzymes and inhibits them by binding to their amino acid residues. This binding prevents the enzyme from functioning correctly and leads to cell death. 5-fluoro-2,2-dimethyl-indoline works by inhibiting class A β lactamases which are found in Gram negative bacteria and some Gram positive bacteria such as Clostridium difficile. It also inhibits peptidoglycan synthesis by binding to the peptidyl transferase or ribosome, which prevents protein synthesis.
Chemical properties
Technical inquiry about: 3D-FF79807 5-fluoro-2,2-dimethyl-indoline
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