Product Information
- 4-Thio-5-fdump
- 4-Thio-5-fluoro-dump
- 5-Fluoro-4-thio-2'-deoxyuridine 5'-monophosphate
- 5-Fluoro-4-thio-2'-dump
- 5'-Uridylic acid, 2'-deoxy-5-fluoro-4-thio-
- 1-(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)-5-fluoro-4-thioxo-3,4-dihydropyrimidin-2(1H)-one
5-Fluoro-4-Thio-2'-Deoxyuridylate is a competitive inhibitor of thymidylate synthase. It has been shown to inhibit the enzymatic activity of this enzyme and prevent the formation of nucleotides in cells. 5-Fluoro-4-Thio-2'-Deoxyuridylate binds to the active site of the enzyme and prevents the reaction from occurring by blocking access to its substrate, uridine. 5FDU is a congener for 5FU, which is an anticancer drug that is used in chemotherapy. 5FDU inhibits muscle cell growth and can be used as a potential treatment for muscular dystrophy. The mechanism of action for this drug is a nucleophilic attack on the sulfur atom in the enzyme's active site.
Chemical properties
Technical inquiry about: 3D-FF81077 5-Fluoro-4-Thio-2'-Deoxyuridylate
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