Product Information
- 6-Fluoro-9-beta-d-ribofuranosylpurine
- 9H-Purine, 6-fluoro-9-beta-D-ribofuranosyl-
6-Fluoro-9-beta-D-Ribofuranosyl-9H-Purine (6FdRP) is a metabolite of cisplatin, an anticancer agent. Cisplatin is used in the treatment of various types of cancer. 6FdRP inhibits DNA synthesis by competitively binding to the active site of thymidylate synthase, which is responsible for the production of thymidine from deoxyuridine monophosphate. This drug also inhibits cellular protein synthesis and can produce teratogenic effects in infants if administered during pregnancy. 6FdRP has been shown to inhibit cardiac cells at frequencies below those that cause malformation.
Chemical properties
Technical inquiry about: 3D-FF86175 6-Fluoro-9-β-D-Ribofuranosyl-9H-Purine
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