Guanine hydrochloride hydrate

CAS: 635-39-2

Ref. 3D-FG176004

Product Information

• Name: Guanine hydrochloride hydrate
• Synonyms: 2-Amino-1,7-dihydro-6H-purin-6-one hydrochloride (1:1), 2-Amino-1,9-dihydro-6H-purin-6-one chlorhydrate, 2-Amino-1,9-dihydro-6H-purin-6-one hydrochloride, 2-Amino-1,9-dihydro-6H-purin-6-one hydrochloride (1:1), 2-Amino-1,9-dihydro-6H-purin-6-onhydrochlorid, 2-Amino-9H-purin-6-ol hydrochloride (1:1), 2-amino-3,5-dihydro-6H-purin-6-one, 2-amino-3,7-dihydro-6H-purin-6-one hydrochloride (1:1), 251-661-9, 6H-Purin-6-one, 2-amino-1,7-dihydro-, monohydrochloride, 6H-purin-6-one, 2-amino-1,7-dihydro-, hydrochloride (1:1), 6H-purin-6-one, 2-amino-1,9-dihydro-, hydrochloride (1:1), Guanine, monohydrochloride, Guaninium chloride
• CAS: 635-39-2

Description

Guanine hydrochloride hydrate is a guanine-based nucleoside analogue that inhibits the synthesis of DNA and RNA. It has been used in the treatment of leukemia and myelodysplastic syndrome. Guanine hydrochloride hydrate binds to the enzyme thioguanine synthase, which converts guanine into thioguanine, thereby preventing its conversion into other nucleotide analogues. The binding of Guanine hydrochloride hydrate to thioguanine synthase is reversible, making this drug an attractive therapeutic option for treating hematological malignancies.

• Brand: Biosynth

Chemical properties

• Formula: C₅H₅N₅O·HCl·xH₂O
• Purity: Min. 95%