Z-Gly-Phe-OH

CAS: 1170-76-9

Ref. 3D-FG47278

Product Information

• Name: Z-Gly-Phe-OH
• Synonyms: Z-L-glycyl-L-phenylalanine, (2S)-2-[[2-(Benzyloxycarbonylamino)acetyl]amino]-3-phenyl-propanoic acid, (2S)-3-Phenyl-2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]propanoic acid, (Carbobenzoxy)glycyl-<span class="text-smallcaps">L</span>-phenylalanine, (Carbobenzoxy)glycylphenylalanine, (Carbobenzyloxy)glycyl-<span class="text-smallcaps">L</span>-phenylalanine, <span class="text-smallcaps">L</span>-Alanine, N-(N-carboxyglycyl)-3-phenyl-, N-benzyl ester, <span class="text-smallcaps">L</span>-Phenylalanine, N-[(phenylmethoxy)carbonyl]glycyl-, <span class="text-smallcaps">L</span>-Phenylalanine, N-[N-[(phenylmethoxy)carbonyl]glycyl]-, Alanine, N-(N-carboxyglycyl)-3-phenyl-, N-benzyl ester, <span class="text-smallcaps">L</span>-, Carbobenzoxyglycylphenylalanine, L-Phenylalanine, N-(N-((phenylmethoxy)carbonyl)glycyl)-, N-(Benzyloxycarbonyl)glycyl-<span class="text-smallcaps">L</span>-phenylalanine, N-(Benzyloxycarbonyl)glycylphenylalanine, N-(Carbobenzoxy)glycyl-<span class="text-smallcaps">L</span>-phenylalanine, N-(Carbobenzyloxy)glycyl-<span class="text-smallcaps">L</span>-phenylalanine, N-(N-((Phenylmethoxy)carbonyl)glycyl)-L-phenylalanine, N-[(Phenylmethoxy)carbonyl]glycyl-<span class="text-smallcaps">L</span>-phenylalanine, N-[(benzyloxy)carbonyl]glycyl-L-phenylalanine, N-[(benzyloxy)carbonyl]glycylphenylalanine, Nsc 89642, Z-Gly-Phe-Oh

Description

Z-Gly-Phe-OH is a carboxy terminal amino acid that has been shown to inhibit the binding of sodium carbonate to pancreatic enzymes. This inhibition is reversible and may be due to the formation of a complex between Z-Gly-Phe-OH and the carboxy terminal of the enzyme. The binding constants for this interaction are in the range of 10M. The pH optimum for this interaction is between 7 and 8, with an activation energy of 0.2 kcal/mol. Z-Gly-Phe-OH inhibits pancreatic enzyme activity by competitive inhibition with aliphatic hydrocarbons, aromatic hydrocarbons, and kinetic mechanisms. Sephadex G-100 was used as chromatographic separation material for this study.

• Brand: Biosynth

Chemical properties

• Molecular weight: 356.37 g/mol
• Formula: C₁₉H₂₀N₂O₅
• Purity: Min. 95%
• InChI: InChI=1S/C19H20N2O5/c22-17(12-20-19(25)26-13-15-9-5-2-6-10-15)21-16(18(23)24)11-14-7-3-1-4-8-14/h1-10,16H,11-13H2,(H,20,25)(H,21,22)(H,23,24)/t16-/m0/s1
• InChI key: InChIKey=FLGYJBNDDWLTQR-INIZCTEOSA-N
• SMILES: O=C(CNC(=O)OCc1ccccc1)N[C@@H](Cc1ccccc1)C(=O)O