6-Hydroxynicotinic acid

CAS: 5006-66-6

Ref. 3D-FH02538

Product Information

• Name: 6-Hydroxynicotinic acid
• Synonyms: 6-Hydroxypyridine-3-carboxylic acid, 1,6-Dihydro-6-oxo-3-pyridinecarboxylic acid, 2-Hydroxy-5-Pyridinecarboxylic Acid, 2-Hydroxy-5-carboxypyridine, 2-Hydroxypyridine-5-carboxylic acid, 2-Oxopyridine-5-carboxylic acid, 2-Pyridone-5-carboxylic acid, 3-Pyridinecarboxylic acid, 1,6-dihydro-6-oxo-, 5-Carboxy-2-pyridone, 6-Hydroxy Nicotinic Acid, 6-Hydroxyniacin, 6-Oxo-1,6-Dihydropyridine-3-Carboxylate, 6-Oxo-1,6-dihydro-pyridine-3-carboxylic acid, 6-Oxonicotinic Acid, NSC 35054, NSC 53377, NSC 8620, Nicotinic acid, 1,6-dihydro-6-oxo-, Nicotinic acid, 6-hydroxy-
• CAS: 5006-66-6

Description

6-Hydroxynicotinic acid is a nicotinic acid analogue that has been shown to inhibit bacterial growth, with the exception of Bacillus subtilis. It has been shown to be specific for bacterial nicotinamide adenine dinucleotide (NAD) reductase and NAD+ kinase enzymes, which are involved in the biosynthesis of nicotinamide adenine dinucleotide phosphate (NADP). 6-Hydroxynicotinic acid binds to these enzymes and prevents them from carrying out their normal reactions, leading to decreased ATP production. In vitro assays have also demonstrated that 6-hydroxynicotinic acid inhibits human epidermal growth factor receptor (EGFR) tyrosine phosphorylation, thereby inhibiting its signalling pathway.

• Brand: Biosynth

Chemical properties

• Molecular weight: 139.11 g/mol
• Formula: C₆H₅NO₃
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C6H5NO3/c8-5-2-1-4(3-7-5)6(9)10/h1-3H,(H,7,8)(H,9,10)
• InChI key: InChIKey=BLHCMGRVFXRYRN-UHFFFAOYSA-N
• SMILES: O=C(O)c1ccc(=O)[nH]c1