trans-3-Hydroxycotinine

CAS: 34834-67-8

Ref. 3D-FH09568

Product Information

• Name: trans-3-Hydroxycotinine
• Synonyms: (3R,5S)-3-Hydroxy-1-methyl-5-(3-pyridinyl)-2-pyrrolidinone(3'R,5'S)-3'-Hydroxycotinine, (3R,5S)-3-Hydroxy-1-methyl-5-(3-pyridinyl)-2-pyrrolidinone, (3S-trans)-3-Hydroxycotinine, (3′R,5′S)-3′-Hydroxycotinine, 2-Pyrrolidinone, 3-hydroxy-1-methyl-5-(3-pyridinyl)-, (3R,5S)-, 2-Pyrrolidinone, 3-hydroxy-1-methyl-5-(3-pyridinyl)-, (3R-trans)-, 34834-67-8, Cotinine, hydroxy-, Hydroxycotinine, trans-1-Methyl-3(R)-hydroxy-5(S)-3-pyridyl-2-pyrrolidinone, trans-3′-Hydroxycotinine
• CAS: 34834-67-8

Description

Trans-3-hydroxycotinine is a metabolite of nicotine that is formed in the liver. It is produced from 3-hydroxycotinine by cytochrome P450 2A6 and 2A13, which are enzymes found in the liver. Trans-3-hydroxycotinine can be detected in blood samples using a LC-MS/MS method. The analytical method for trans-3-Hydroxycotinine has been developed by measuring the concentration of cotinine, an intermediate metabolite of nicotine. The matrix effect may interfere with the measurement of trans-3-Hydroxycotinine concentrations, and should be taken into account when calibrating the analytical method. Trans-3-hydroxycotinine has been shown to inhibit ATP dependent transport and glucuronide conjugation enzymes, which are involved in detoxification reactions. This compound also inhibits human serum esterase activity at high concentrations.

• Brand: Biosynth

Chemical properties

• Molecular weight: 192.22 g/mol
• Formula: C₁₀H₁₂N₂O₂
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C10H12N2O2/c1-12-8(5-9(13)10(12)14)7-3-2-4-11-6-7/h2-4,6,8-9,13H,5H2,1H3/t8-,9+/m0/s1
• InChI key: InChIKey=XOKCJXZZNAUIQN-DTWKUNHWSA-N
• SMILES: CN1C(=O)[C@H](O)C[C@H]1c1cccnc1