3-Hydroxy-2-naphthohydrazide

CAS: 5341-58-2

Ref. 3D-FH112870

Product Information

• Name: 3-Hydroxy-2-naphthohydrazide
• Synonyms: 2-Hydroxy-3-naphthoic acid hydrazide, 2-Hydroxy-3-naphthoic hydrazide, 2-Hydroxy-3-naphthoylhydrazine, 2-Hydroxynaphthalene-1,4-Dione, 2-Naphthalenecarboxylic acid, 3-hydroxy-, hydrazide, 2-Naphthoic acid, 3-hydroxy-, hydrazide, 3-Hydroxy-2-Naphthohydrazide, 3-Hydroxy-2-naphthoic hydrazide, 3-Hydroxy-2-naphthoylhydrazine, 3-Hydroxy-2-naphthydrazide, 3-Hydroxynaphthalene-2-Carbohydrazide, 3-Hydroxynaphthalene-2-carboxylic acid hydrazide, 3-Hydroxynaphthalene-2-carboxylic hydrazide, NSC 2117, NSC 49198

Description

3-Hydroxy-2-naphthohydrazide is a reactive compound that can be formed from the metabolism of fatty acids. It binds to and inhibits epidermal growth factor receptors, which are involved in cell proliferation. 3-Hydroxy-2-naphthohydrazide has been shown to inhibit the growth of human cancer cells in culture, including carcinoma cell lines. This drug also has an effect on tumor size and weight in experimental models. 3-Hydroxy-2-naphthohydrazide is a competitive inhibitor of the binding of epidermal growth factor (EGF) to its receptor and can be used as an experimental model for EGF. The effects of this drug on tumor size and weight were seen when it was injected into mice with liver tumors.

• Brand: Biosynth

Chemical properties

• Molecular weight: 202.21 g/mol
• Formula: C₁₁H₁₀N₂O₂
• Purity: Min. 95%
• InChI: InChI=1S/C11H10N2O2/c12-13-11(15)9-5-7-3-1-2-4-8(7)6-10(9)14/h1-6,14H,12H2,(H,13,15)
• InChI key: InChIKey=FDNAQCWUERCJBK-UHFFFAOYSA-N
• SMILES: NNC(=O)c1cc2ccccc2cc1O