7-Hydroxy-3-phenyl-chromen-4-one

CAS: 13057-72-2

Ref. 3D-FH12874

Product Information

• Name: 7-Hydroxy-3-phenyl-chromen-4-one
• Synonyms: 7-Hydroxyisoflavone, 3-Phenyl-7-hydroxy-4H-1-benzopyran-4-one, 4H-1-Benzopyran-4-one, 7-hydroxy-3-phenyl-, 7-Hydroxy Isoflavone, 7-Hydroxy-3-phenyl-4H-1-benzopyran-4-one, 7-Hydroxy-3-phenylchromen-4-one, 7-Hydroxy-3-phenylchromone, 7-hydroxy-3-phenyl-4H-chromen-4-one, Isoflavone, 7-hydroxy-, NSC 607392
• CAS: 13057-72-2

Description

7-Hydroxy-3-phenyl-chromen-4-one is a chemical compound that is used as an antimicrobial agent. It has been shown to inhibit protein synthesis in myocardial cells, which may contribute to the development of heart disease. 7-Hydroxy-3-phenyl-chromen-4-one binds to the ribosome and prevents protein synthesis by inhibiting elongation of the polypeptide chain. This inhibition of protein synthesis by 7HPCO is reversible and may be due to hydrogen bonding between its hydroxyl group and the phosphate groups on the ribosome. The binding constants for 7HPCO are in the low micromolar range, with a Kd value of 0.13 μM for erythromycin A. This suggests that there are similarities in their mechanisms of action, as well as pharmacokinetics profiles.

• Brand: Biosynth

Chemical properties

• Molecular weight: 238.24 g/mol
• Formula: C₁₅H₁₀O₃
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C15H10O3/c16-11-6-7-12-14(8-11)18-9-13(15(12)17)10-4-2-1-3-5-10/h1-9,16H
• InChI key: InChIKey=WMKOZARWBMFKAS-UHFFFAOYSA-N
• SMILES: O=c1c(-c2ccccc2)coc2cc(O)ccc12