Hydrocortisone 17-butyrate 21-propionate

CAS: 72590-77-3

Ref. 3D-FH23884

Product Information

• Name: Hydrocortisone 17-butyrate 21-propionate
• Synonyms: (11b)-11-Hydroxy-17-(1-oxobutoxy)-21-(1-oxopropoxy)pregn-4-ene-3,20-dione17a-Butyryloxy-11b-hydroxy-21-propionyloxy-4-pregnene-3,20 -dioneHydrocortisone buteprate, (11Beta)-11-Hydroxy-3,20-Dioxo-21-(Propanoyloxy)Pregn-4-En-17-Yl Butanoate, (11β)-11-Hydroxy-17-(1-oxobutoxy)-21-(1-oxopropoxy)pregn-4-ene-3,20-dione, (9Xi,11Beta)-11-Hydroxy-3,20-Dioxo-21-(Propanoyloxy)Pregn-4-En-17-Yl Butanoate, 17α-Butyryloxy-11β-hydroxy-21-propionyloxy-4-pregnene-3,20-dione, Hydrocortisone Probutate, Hydrocortisone buteprate, Pandel, Pregn-4-ene-3,20-dione, 11-hydroxy-17-(1-oxobutoxy)-21-(1-oxopropoxy)-, (11β)-, Ts 408

Description

Hydrocortisone 17-butyrate 21-propionate is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. This drug is a prodrug that is hydrolyzed in the liver to hydrocortisone, its active form, by esterases. Hydrocortisone 17-butyrate 21-propionate has been used to treat inflammatory bowel disease and various skin disorders. It also has been shown to inhibit the production of malonic acid, which may be due to inhibition of fatty acid synthase and/or enhanced absorption of hydrocortisone from the gastrointestinal tract. The drug also interacts with other drugs such as dimethyl fumarate, which inhibits the metabolism of hydrocortisone by cytochrome P450 enzymes. This can lead to increased blood concentrations of hydrocortisone and serious side effects such as metabolic disorders or high blood pressure.

• Brand: Biosynth

Chemical properties

• Molecular weight: 488.61 g/mol
• Formula: C₂₈H₄₀O₇
• Purity: Min. 95%
• Color/Form: White/Off-White Solid