3-Hydroxy desloratadine

CAS: 119410-08-1

Ref. 3D-FH23974

Product Information

• Name: 3-Hydroxy desloratadine
• Synonyms: 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-ol3-HydroxydesloratadineSch 45581, 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-ol, Sch 45581, 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-ol, 3-Hydroxydesloratadine
• CAS: 119410-08-1

Description

3-Hydroxy desloratadine is a metabolite of desloratadine. It is one of the metabolites that can be formed from the drug in vivo, after oral administration. 3-Hydroxy desloratadine has been shown to be an active metabolite in vitro and in vivo, with linear calibration curves (R2>0.99) for both human liver and human plasma samples. The metabolic profile of 3-hydroxy desloratadine is similar to that of desloratadine, including inhibition of cytochrome P450 enzymes and glucuronidation by glucuronidases. In vitro studies have shown that 3-hydroxy desloratadine is not a substrate for CYP2D6 or CYP3A4, but it may inhibit CYP1A2 and CYP2C19. It has also been shown to be a substrate for UGT1A6 and UGT2B7.

• Brand: Biosynth

Chemical properties

• Molecular weight: 326.82 g/mol
• Formula: C₁₉H₁₉ClN₂O
• Purity: Min. 95%