12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid

CAS: 54397-83-0

Ref. 3D-FH24172

Product Information

• Name: 12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid
• Synonyms: [S-(E,Z,Z,Z)]-12-Hydroxy-5,8,10,14-eicosatetraenoic acid12-HETE12-Hydroxy-5,8,10,14-eicosatetraenoic acid, (12S,5Z,8Z,10E,14Z)-12-Hydroxyeicosatetraenoic acid, (5Z,8Z,10E,12S,14Z)-12-Hydroxy-5,8,10,14-eicosatetraenoic acid, (5Z,8Z,10E,12S,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid, 12(S)-Hete, 12(S)-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid, 12(S)-Hydroxy-5,8,14-cis-10-trans-eicosatetraenoic acid, 12-<span class="text-smallcaps">L</span>-Hydroxy-5,8,10,14-eicosatetraenoic acid, 12-Hete, 12-Hydroxy-5,8,10,14-eicosatetraenoic acid, 12-Hydroxyeicosatetraenoic acid, 12-Hydroxyicosa-5,8,10,14-Tetraenoic Acid, 12S-Hydroxy-5,8,10,14-(Z,Z,E,Z)-eicosatetraenoic acid, 12S-Hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid, 5,8,10,14-Eicosatetraenoic acid, 12-hydroxy-, (5Z,8Z,10E,12S,14Z)-, 5,8,10,14-Eicosatetraenoic acid, 12-hydroxy-, [S-(E,Z,Z,Z)]-, 12-L-Hydroxy-5,8,10,14-eicosatetraenoic acid

Description

12-(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) is an unsaturated fatty acid that is formed by the hydrolysis of arachidonic acid. It has been shown to have anti-inflammatory effects in vitro and in vivo, as well as inhibitory properties on guanine nucleotide-binding proteins, integrin receptors, and polymerase chain reaction. 12(S)-HETE also has pro-apoptotic properties, which are mediated by a decrease in intracellular calcium levels. This compound has shown to regulate the mitochondrial functions of 3t3-l1 preadipocytes and HL-60 cells.

• Brand: Biosynth

Chemical properties

• Molecular weight: 320.47 g/mol
• Formula: C₂₀H₃₂O₃
• Purity: Min. 95%