Product Information
Name:(2E)-1-(2-Hydroxyphenyl)-3-phenyl-2-propen-1-one
Synonyms:
- (E)-2'-Hydroxy-chalcone(E)-o-Hydroxyphenyl styryl ketoneNSC 170284
Brand:Biosynth
Description:The 2-hydroxyphenyl-3-phenylpropenal (HPPA) is a fatty acid with a hydroxyl group. It has been shown to have anti-inflammatory properties and inhibit the production of TNF-α in mice. HPPA is synthesized by the oxidation of oleic acid, which can be catalyzed by a number of different enzymes such as lipoxygenases, cyclooxygenases, or cytochrome P450s. The synthesis can also be inhibited by other substances such as dibromides or tnf-α. HPPA also has potent inhibitory activity against transcription polymerase chain reaction and protein synthesis. This inhibition is due to its carbonyl group that reacts with the intramolecular hydrogen on the enzyme's active site. The reaction mechanism for this inhibition is similar to that of propranolol, another drug used for treatment of inflammatory diseases.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:224.25 g/mol
Formula:C15H12O2
Purity:Min. 95%
Color/Form:Powder
InChI:InChI=1S/C15H12O2/c16-14-9-5-4-8-13(14)15(17)11-10-12-6-2-1-3-7-12/h1-11,16H/b11-10+
InChI key:InChIKey=AETKQQBRKSELEL-ZHACJKMWSA-N
SMILES:O=C(/C=C/c1ccccc1)c1ccccc1O
Technical inquiry about: (2E)-1-(2-Hydroxyphenyl)-3-phenyl-2-propen-1-one
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