2-Hydroxyisonicotinic acid

CAS: 22282-72-0

Ref. 3D-FH50815

Product Information

• Name: 2-Hydroxyisonicotinic acid
• Synonyms: 2-Hydroxy-4-pyridinecarboxylic acid4-Carboxy-2(1H)-pyridinone, 2-Hydroxy-4-pyridinecarboxylic acid, 2-Hydroxy-Isonicotinic Acid, 2-Hydroxypyridine-4-Carboxylic Acid
• CAS: 22282-72-0

Description

2-Hydroxyisonicotinic acid is a synthetic analog of isonicotinic acid that is used as a nonheme iron chelator. It has been shown to inhibit the growth of cavity-causing bacteria in vitro by binding to iron enzymes, such as methane monooxygenase and n-oxide reductase. 2-Hydroxyisonicotinic acid inhibits bacterial growth by binding to the enzyme complexes containing iron, thereby inhibiting the synthesis of fatty acids and pyridine compounds. X-ray crystal structures have also shown that this compound binds to the nonheme iron at two sites, which may explain its ability to inhibit bacterial growth.

• Brand: Biosynth

Chemical properties

• Molecular weight: 139.11 g/mol
• Formula: C₆H₅NO₃
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C6H5NO3/c8-5-3-4(6(9)10)1-2-7-5/h1-3H,(H,7,8)(H,9,10)
• InChI key: InChIKey=BXHCJLRTXPHUGH-UHFFFAOYSA-N
• SMILES: O=C(O)c1cc[nH]c(=O)c1