4-Hydroxyquinoline-3-carboxylic acid

CAS: 34785-11-0

Ref. 3D-FH57063

Product Information

• Name: 4-Hydroxyquinoline-3-carboxylic acid
• Synonyms: 4-Hydroxy-3-quinolinecarboxylicacid, Nsc 4344, 4-Hydroxyquinoline-3-Carboxylicacid

Description

4-Hydroxyquinoline-3-carboxylic acid is a quinoline derivative with potent antibacterial activity. It has been shown to be active against Gram-positive bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, and Enterococcus faecalis. The mechanism of action involves the inhibition of bacterial DNA gyrase and topoisomerase IV. This drug also has anti-HIV activity, which may be due to its ability to bind to HIV receptors and inhibit the virus' entry into cells. 4-Hydroxyquinoline-3-carboxylic acid has been shown in vitro to inhibit the replication of HIV in human T cells, macrophages, and lymphocytes.

• Brand: Biosynth

Chemical properties

• Molecular weight: 189.17 g/mol
• Formula: C₁₀H₇NO₃
• Purity: Min. 95%
• InChI: InChI=1S/C10H7NO3/c12-9-6-3-1-2-4-8(6)11-5-7(9)10(13)14/h1-5H,(H,11,12)(H,13,14)
• InChI key: InChIKey=ILNJBIQQAIIMEY-UHFFFAOYSA-N
• SMILES: O=C(O)c1c[nH]c2ccccc2c1=O