![8-Hydroxy-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline-9-carbaldehyde](https://static.cymitquimica.com/products/3D/img/FH58873.png "Click to enlarge")
8-Hydroxy-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline-9-carbaldehyde
CAS: 63149-33-7
Ref. 3D-FH58873
| 1g | 284.00 € | ||
| 5g | 959.00 € |
Product Information
- 9-Formyl-8-hydroxyjulolidine
- 1H,5H-Benzo(ij)quinolizine-9-carboxaldehyde, 2,3,6,7-tetrahydro-8-hydroxy-
- 8-Hydroxyjulolidine-9-carboxaldehyde
- 9-Formyl-8-hydroxy-2,3,6,7-tetrahydro-1H,5H-benzo[ij]quinolizine
- 9-Formyl-8-julolidinol
8-Hydroxy-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline-9-carbaldehyde (8OHPQCA) is a chemical species that exhibits biological properties. It has been shown to be a platinum-based chemotherapy drug and it is the first experimental platinum anticancer agent with low toxicity. 8OHPQCA inhibits the growth of mammalian cells by binding to DNA and inhibiting synthesis of proteins. The mechanism of action involves the formation of hydrogen bonds between 8OHPQCA and protonated guanine in DNA. This leads to intramolecular hydrogen bonding and a decrease in the optical properties of 8OHPQCA. Hydrolysis by enzymes such as mitochondrial matrix lead to release of free radicals that are cytotoxic. 8OHPQCA can also bind to magnetic resonance spectroscopy probes for low detection and optical sensors for
Chemical properties
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