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1H-Indazol-3-ylamine
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1H-Indazol-3-ylamine

CAS: 874-05-5

Ref. 3D-FI16217

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Estimated delivery in United States, on Monday 30 Dec 2024

Product Information

Name:
1H-Indazol-3-ylamine
Synonyms:
  • 1H-Indazol-3-Ylamine
  • 1H-Indazole, 3-amino-
  • 1H-Indazole,3-amino- (6CI,7CI,8CI)
  • 3-Amino-1H-indazole
  • 3-Aminoindazole
  • 3-Indazolamine
  • Nsc 348887
  • Nsc 44677
Description:

1H-Indazol-3-ylamine is a novel drug that has been shown to inhibit the Abl kinase. The drug binds to the ATP binding site at the N-terminus of the kinase and prevents ATP from activating the kinase. It also inhibits the phosphorylation of Bcr-Abl, which is essential for its growth and survival. 1H-Indazol-3-ylamine has been shown to be active against cells with a high level of bcr-abl kinase activity, such as K562 leukemia cells, in transfection experiments. This drug also inhibits Bcr-Abl tyrosine phosphorylation and blocks signals downstream of Bcr-Abl, such as protein synthesis and cell division.
1H-Indazol-3-ylamine has been found to have potential anticancer activity against atherosclerotic cardiovascular disease (CVD) in mice models by inhibiting lipid accumulation in

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
133.15 g/mol
Formula:
C7H7N3
Purity:
Min. 95%
MDL:
Melting point:
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EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
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Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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