1H-Indazol-3-ylamine

CAS: 874-05-5

Ref. 3D-FI16217

Product Information

• Name: 1H-Indazol-3-ylamine
• Synonyms: 1H-Indazol-3-Ylamine, 1H-Indazole, 3-amino-, 1H-Indazole,3-amino- (6CI,7CI,8CI), 3-Amino-1H-indazole, 3-Aminoindazole, 3-Indazolamine, Nsc 348887, Nsc 44677
• CAS: 874-05-5

Description

1H-Indazol-3-ylamine is a novel drug that has been shown to inhibit the Abl kinase. The drug binds to the ATP binding site at the N-terminus of the kinase and prevents ATP from activating the kinase. It also inhibits the phosphorylation of Bcr-Abl, which is essential for its growth and survival. 1H-Indazol-3-ylamine has been shown to be active against cells with a high level of bcr-abl kinase activity, such as K562 leukemia cells, in transfection experiments. This drug also inhibits Bcr-Abl tyrosine phosphorylation and blocks signals downstream of Bcr-Abl, such as protein synthesis and cell division.
1H-Indazol-3-ylamine has been found to have potential anticancer activity against atherosclerotic cardiovascular disease (CVD) in mice models by inhibiting lipid accumulation in

• Brand: Biosynth

Chemical properties

• Molecular weight: 133.15 g/mol
• Formula: C₇H₇N₃
• Purity: Min. 95%