Isobarbituric acid

CAS: 496-76-4

Ref. 3D-FI24655

Product Information

• Name: Isobarbituric acid
• Synonyms: 2,4,5-TrihydroxypyrimidineDihydro-2,4,5(3H)-pyrimidinetrione5-Hydroxyuracil, 1,3-Diazinane-2,4,5-trione, 2,4,5(3H)-Pyrimidinetrione, dihydro-, 5-Hydroxyuracil, 5-hydroxypyrimidine-2,4(1H,3H)-dione, Dihydro-2,4,5(3H)-pyrimidinetrione, NSC 95958, dihydropyrimidine-2,4,5(3H)-trione
• CAS: 496-76-4

Description

Isobarbituric acid is a glycosylase that cleaves the bond between the amino group and the hydroxyl group of uridine in DNA. It has been shown to react with nucleophilic groups at neutral pH, such as an amine or hydroxyl group. Isobarbituric acid can be used to measure oxidative damage to DNA. This compound is reactive and sensitive to UV light, which makes it useful for detecting damaged DNA. Isobarbituric acid has been shown to induce neuronal death in rodents by interfering with dendritic spine formation.

• Brand: Biosynth

Chemical properties

• Molecular weight: 128.09 g/mol
• Formula: C₄H₄N₂O₃
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C4H4N2O3/c7-2-1-5-4(9)6-3(2)8/h1H2,(H2,5,6,8,9)
• InChI key: InChIKey=FQXOOGHQVPKHPG-UHFFFAOYSA-N
• SMILES: O=C1NCC(=O)C(=O)N1