(-)-Isocorypalmine

CAS: 483-34-1

Ref. 3D-FI24671

Product Information

• Name: (-)-Isocorypalmine
• Synonyms: (13aS)-5,8,13,13a-Tetrahydro-3,9,10-trimethoxy-6H-dibenzo[a,g]quinolizin-2-olTetrahydro-columbamine2-O-Desmethyl-L-THP, 6H-Dibenzo[a,g]quinolizin-2-ol, 5,8,13,13a-tetrahydro-3,9,10-trimethoxy-, (S)-, Columbamine, tetrahydro-, 13aα-Berbin-2-ol, 3,9,10-trimethoxy-, 6H-Dibenzo[a,g]quinolizin-2-ol, 5,8,13,13a-tetrahydro-3,9,10-trimethoxy-, (13aS)-, Isocorypalmine

Description

(-)-Isocorypalmine is a protopine-type alkaloid that is found in the root of Angelica dahurica. (-)-Isocorypalmine has been shown to have antimicrobial activity against human pathogens, including Helicobacter pylori and Campylobacter jejuni. This compound has also been shown to synergize with other antimicrobial agents, such as amoxicillin, erythromycin, and penicillin G. The synergistic effect between (-)-isocorypalmine and these agents may be due to the inhibition of some bacterial enzymes by (-)-isocorypalmine, including matrix metalloproteinase and protease activities. Furthermore, (-)-isocorypalmine has shown antipsychotic effects in animal models when administered orally. This compound binds to dopamine receptors, which may account for its effect on locomotor activity. It also inhibits monoamine oxidases (MAO) A and B.

• Brand: Biosynth

Chemical properties

• Molecular weight: 341.4 g/mol
• Formula: C₂₀H₂₃NO₄
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C20H23NO4/c1-23-18-5-4-12-8-16-14-10-17(22)19(24-2)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,9-10,16,22H,6-8,11H2,1-3H3/t16-/m0/s1
• InChI key: InChIKey=KDFKJOFJHSVROC-INIZCTEOSA-N
• SMILES: COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2