Isovaleryl-Phe-Nle-Sta-Ala-Sta-OH
CAS: 98092-14-9
Ref. 3D-FI49358
| 1mg | 400.00 € | ||
| 2mg | 569.00 € | ||
| 5mg | 948.00 € | ||
| 10mg | 1,593.00 € |
Product Information
- N-(3-methylbutanoyl)-L-phenylalanyl-N-[(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl]-N-[(2S)-2-({1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl}amino)propanoyl]-L-norleucinamide
Isovaleryl-Phe-Nle-Sta-Ala-Sta-OH (IVAS) is a small molecule that has been shown to be an angiotensin system inhibitor. IVAS blocks the binding site of the angiotensin receptor and prevents the activation of this system. This effect is dose dependent and can be used to treat high blood pressure in humans. IVAS is a long-acting drug and has been shown to be effective in primates as well as humans. The drug is rapidly absorbed from the gastrointestinal tract and eliminated by metabolism, mainly through hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. IVAS also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.
Chemical properties
Technical inquiry about: 3D-FI49358 Isovaleryl-Phe-Nle-Sta-Ala-Sta-OH
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