2-(Isopropylsulphonyl)aniline

CAS: 76697-50-2

Ref. 3D-FI75046

Product Information

• Name: 2-(Isopropylsulphonyl)aniline
• Synonyms: 1-Amino-2-(isopropylsulfonyl)benzene, 2-Isopropylsulfonylaniline, 1-Amino-2-(isopropylsulphonyl) benzene, 2-(Isopropylsulfonyl)Aniline, 2-(Propane-2-Sulfonyl)-Phenylamine, 2-(Isopropylsulfonyl)Benzenamine
• CAS: 76697-50-2

Description

2-(Isopropylsulphonyl)aniline (2-ISA) is a potent and selective inhibitor of the mitotic checkpoint kinase Mad2, which is implicated in cancer. 2-ISA has been shown to inhibit the mitotic spindle assembly checkpoint by binding to Mad2 and inhibiting its ability to phosphorylate Mad1 and Cdc20. In vitro experiments have demonstrated that 2-ISA blocks cell cycle progression in ht-29 cells, a colon cancer cell line, by preventing their entry into mitosis. 2-ISA has been shown to be an effective inhibitor of tumor growth in vivo. This agent also inhibits sorafenib, a drug that targets the Raf/MEK/ERK signaling pathway and is used for the treatment of cancer. The analogs of 2-ISA are being developed as potential anticancer agents.

• Brand: Biosynth

Chemical properties

• Molecular weight: 199.27 g/mol
• Formula: C₉H₁₃NO₂S
• Purity: Min. 95%
• InChI: InChI=1S/C9H13NO2S/c1-7(2)13(11,12)9-6-4-3-5-8(9)10/h3-7H,10H2,1-2H3
• InChI key: InChIKey=GMLAMRMKROYXNZ-UHFFFAOYSA-N
• SMILES: CC(C)S(=O)(=O)c1ccccc1N