D-Kynurenine

CAS: 13441-51-5

Ref. 3D-FK145481

Product Information

• Name: D-Kynurenine
• Synonyms: (2R)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid, (αR)-α,2-Diamino-γ-oxobenzenebutanoic acid, <span class="text-smallcaps">D</span>-Kynurenine, Alanine, 3-anthraniloyl-, <span class="text-smallcaps">D</span>-, Benzenebutanoic acid, α,2-diamino-γ-oxo-, (R)-, Benzenebutanoic acid, α,2-diamino-γ-oxo-, (αR)-
• CAS: 13441-51-5

Description

D-Kynurenine is a product of tryptophan metabolism that has been shown to be involved in the development of cancer. It has been shown to inhibit acetylcholine release and cause cell death in rats. D-Kynurenine also acts as a chemoattractant for white blood cells, and it is thought to be involved in the regulation of camp levels. In humans, d-kynurenine is produced by the enzyme quinolinate phosphoribosyltransferase from 3-hydroxyanthranilic acid, which is converted from L-tryptophan by the enzyme indoleamine 2,3-dioxygenase. The optimum pH for this reaction is 7.4 and its maximum activity occurs at 37°C. D-Kynurenine may have therapeutic potential for the treatment of acetylcholine deficiency diseases such as Alzheimer's disease or Parkinson's disease due to its ability to increase acetylch

• Brand: Biosynth

Chemical properties

• Molecular weight: 208.21 g/mol
• Formula: C₁₀H₁₂N₂O₃
• Purity: Min. 95%
• InChI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m1/s1
• InChI key: InChIKey=YGPSJZOEDVAXAB-MRVPVSSYSA-N
• SMILES: Nc1ccccc1C(=O)C[C@@H](N)C(=O)O