H-Leu-Phe-OH

CAS: 3063-05-6

Ref. 3D-FL108098

Product Information

• Name: H-Leu-Phe-OH
• Synonyms: 165: PN: WO2010045512 SEQID: 174 unclaimed protein, 218: PN: EP2161028 PAGE: 11 claimed protein, 301: PN: WO2014145242 PAGE: 31 claimed protein, 326: PN: WO2010059829 SEQID: 354 unclaimed protein, 45: PN: WO2020097235 SEQID: 274 claimed protein, <span class="text-smallcaps">L</smallcap>-Leucyl-<smallcap>L</span>-phenylalanine, <span class="text-smallcaps">L</smallcap>-Phenylalanine, <smallcap>L</span>-leucyl-, <span class="text-smallcaps">L</smallcap>-Phenylalanine, N-<smallcap>L</span>-leucyl-, Alanine, N-<span class="text-smallcaps">L</smallcap>-leucyl-3-phenyl-, <smallcap>L</span>-, Alanine, N-<span class="text-smallcaps">L</span>-leucyl-3-phenyl-, Alanine, N-leucyl-3-phenyl-, L-Leucyl-L-phenylalanine, Leucylphenylalanine, NSC 89191
• CAS: 3063-05-6

Description

H-Leu-Phe-OH is a synthetic substrate that has been shown to bind to neutrophils and induce chemotactic activity. H-Leu-Phe-OH binds to the receptor on the surface of neutrophils and increases their recruitment to sites of inflammation. Studies have shown that H-Leu-Phe-OH can also stimulate production of interleukin, which may be useful in treating systemic diseases such as chronic kidney disease. H-Leu-Phe-OH is expressed at high levels in glomeruli, where it is secreted into the glomerular filtrate by proximal tubules. The biological effects of this substance are mediated by intracellular calcium ion release from intracellular stores, which leads to increased levels of messenger RNA for monoclonal antibody production and protein synthesis in neutrophils.

• Brand: Biosynth

Chemical properties

• Molecular weight: 278.35 g/mol
• Formula: C₁₅H₂₂N₂O₃
• Purity: Min. 95%